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Overexpressing FTMT or mCAT diminished mitochondrial lipid peroxidation and cell death induced by sI/R, associated with reduced HMGB1 release (Fig

Sappl et al., 2004, 2009)

The 2016 Noh investigation in International Journal of Molecular Sciences documented novel anti-melanogenesis properties of PDRN, identifying inhibition of microphthalmia-associated transcription factor (MITF) as the mechanism by which PDRN reduces melanin synthesis

,, Although there are several inhibitors of the cystine/glutamate transporter other than sulfasalazine, these drugs have limitations of low bioavailability and low selectivity to of the cystine/glutamate transporter in vivo