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Clinical signs of mechanism activation Neuroprotective mechanisms: Stabilized or slowed visual field loss (glaucoma), maintained ganglion cell layer thickness on OCT, preserved optic nerve appearance

Martinovits G, Melamed E, Cohen O, Rosenthal J, Uzzan A (1986) Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)