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Key Legislative Changes The introduction of updated Tobacco and Related Products Regulations in 2016 marked a major legislative shift, imposing stricter controls on nicotine levels, container sizes, and mandatory child-resistant packaging

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1 H NMR (500 MHz, DMSO) 8.007.96 (m, 2H), 7.92 (dd, J = 7.9, 1.5 Hz, 1H), 7.657.61 (m, 1H), 7.427.38 (m, 2H), 7.36 (d, J = 8.0 Hz, 1H), 7.347.31 (m, 1H), 5.91 (d, J = 5.5 Hz, 1H), 5.90 (s, 1H), 4.344.28 (m, 2H), 4.23 (dd, J = 10.0, 5.5 Hz, 1H), 3.67 (dd, J = 13.5, 4.5 Hz, 1H), 3.51 (dd, J = 12.5, 7.0 Hz, 1H)

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