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Docking simulation of (2 S ,3 S )- t -ES-l-Phe ( 15 ) with Cp1B showed that the side chain of l-Phe can also be housed in the same hydrophobic pocket, suggesting that the MES-binding site could be where the side chain of the l-amino acid binds (Supplementary Fig

The extent and clinical significance of this effect remain subjects of ongoing investigation, and individual responses vary considerably based on genetic factors affecting pigmentation, baseline skin characteristics, concurrent skincare practices and sun exposure, and overall health status affecting skin appearance

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