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This quantitative understanding is now driving the development of pathway-specific inhibitors, such as PKC- selective antagonists, SGLT2 inhibitors, and glyoxalase-1, which have shown promise in preclinical models for breaking this cycle without globally suppressing physiologically important ROS signaling -Figure 3 (Oliveira et al., 2023

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Once the conversion has happened, the release of energy can take place and this process is with the assistance of transport proteins