Primary search terminology included esculetin, 6,7-dihydroxycoumarin, and cichorigenin, combined with disease-specific or mechanism-based terms including esculetin AND inflammation, esculetin AND cancer, esculetin AND diabetes, esculetin AND antioxidant, coumarin AND bioavailability, and coumarin AND derivatives. Disease-specific searches incorporated relevant MeSH headings (neoplasms, cardiovascular diseases, diabetes mellitus, neurodegeneration, and hepatic/renal disorders)
Funding This study was supported by the Pamukkale University Scientific Research Projects Unit (project number: 2021TIPF003)
Improves elasticity, reduces wrinkles, and supports hair growth via collagen and elastin production, with added benefits for conditions like acne, eczema, or psoriasis
Keywords: Epithalon, Epitalon, Synthetic Tetrapeptide, Pineal Peptide Analogue