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These include: modulating key inflammatory pathways decreasing mucosal blood flow causing bowel dysfunction in different ways activating the fight or flight response in the central nervous system which can slow down or even stop the digestive process altering the gut flora, and increasing intestinal permeability

Whereas the microbe-gut-brain axis connects the gut to the brain, and the enteric nervous system (ENS) exists at the interface between the microbiota and the host, the ENS is structurally and neurochemically similar to the CNS, and thus the pathogenic mechanisms that give rise to ENS disorders may also lead to CNS dysfunction and the nerves connecting the ENS to the CNS may act as a conduit for disease transmission (50)

Med Sci Moni

Furthermore, Wang et al