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The Therapeutic Potential of Milk Thistle in Diabetes, The Review of Diabetic Studies, US National Library of Medicine, National Institutes of Health

Phytother Res 20(12):11031105 Panda S, Kar A (2007) Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: possible involvement of quercetin

For instance, young individuals have measurably higher circulating MOTS-c compared to middle-aged and elderly individuals

This causes high oxidative stress, mitochondrial dysfunction, and cell death of the hepatocytes.[ref] As these cells die, inflammatory cascades perpetuate the oxidative stress, leading to bleeding, fibrosis, or possibly liver failure