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Endothelial cells in physiology and pathophysiology. Blood

Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

The physiological characteristics of cells and the high glucose environment associated with diabetes make these cells highly susceptible to death induced by iron and other metal ions