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(1996) first demonstrated that TNF- induces insulin resistance by promoting serine phosphorylation of insulin receptor substrate 1(IRS-1), thereby inhibiting the tyrosine kinase activity of the insulin receptor ( 3.3 The positive feedback loop of hyperandrogenemia Studies have demonstrated that LPS can not only indirectly contribute to hyperandrogenemia by inducing insulin resistance ( 3.4 Adipose tissue dysfunction and metabolic derangements The translocation of LPS into circulation due to intestinal barrier dysfunction disrupts adipose metabolic homeostasis through multiple mechanisms

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Proc Nutr Soc 71:521533

Ethics declarations Ethics approval and consent to participate The adult sheep ovaries were collected from an authorized slaughterhouse, and sperm samples were obtained from the Germplasm Bank of the Reproduction Biology Group, which is officially authorized for collecting and storing semen from sheep (ES07RS02OC)