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of deaths annually 11,000 12,000 2,900 50 100 Rare 0 800,000-1.4 million 2.7-3.9 million 0 3,000 12,000 Abbreviations: HAV, hepatitis A virus

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Remarkably, beneficial effects have been observed across this 100-fold range, suggesting a wide therapeutic window where smaller doses remain biologically active

By selectively interfering with the FOXO4-p53 interaction, FOXO4-DRI has become a compound of interest in research models focused on senescent cell biology and age-associated cellular processes