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This will be discussed in more detail shortly, but it is important to note that a Cause Map diagram is intended to visually depict a chain of events, and would thus be incomplete or unworkable without a link in the chain

14 Nicotine acetylcholine receptors are then activated by a conformational change that opens the internal pore, allowing sodium and calcium ions to enter, 15 leading to glutamate release through the calcium-calmodulin cascades (see Figure 1)

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it simultaneously debuted at numbers four and one on the US Top Latin Albums and Regional Mexican Albums charts, respectively