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It was engineered to reproduce the fat-metabolism activity associated with that region of the GH molecule while remaining distinct from intact growth hormone, which is the rationale behind its use as a fragment tool compound in metabolic research

This mechanism allows individuals to experience fat reduction without the muscle growth or insulin resistance risks often associated with full-spectrum growth hormone therapies

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The human efficacy record is mixed: the fragment cleared safety trials but missed its primary weight endpoint in its largest study, and development for obesity stopped in 2007