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The refill cartridge contains the e-liquid, which is what gives the e-cigarette its taste and (in most cases) its nicotine

Most e-cigarettes operate using four components: a cartridge, reservoir or pod that holds a liquid solution of the nicotine, flavoring and chemicals, heating element, power source and mouthpiece for inhalation

often when a blend bites its a matter of the chemical balance between the tobacco and my body at that moment, and by allowing my palate to remain clear and slowly introducing the blend, I find that equilibrium is achieved in a short time and I can smoke repeated bowls of nearly anything with nary a nip

Am J Respir Cell Mol Biol (2008) 38:68998