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At doses producing equivalent GH release to GHRP-6, Ipamorelin showed no statistically significant elevation of cortisol, prolactin, or aldosterone

ClinicalTrials.gov registry entry NCT05669755 (2025) 8

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Since this formula no longer requires additional GHK peptide for copper complexation, and no other copper source is added, it carries the name CAIS 3 1:1, as a reflection of the ratio of these ingredients in the formulation