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A pharmacy can compound with a bulk substance only if that substance has a USP or NF monograph, is a component of an FDA-approved drug, or appears on the FDAs 503A bulks list

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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider