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Funding This work was supported by grants from National Natural Science Foundation of China (81902668), Yubei District Science and Technology Commission of Chongqing (2020-36) to PY, and National Natural Science Foundation of China Grants (31771545, 91749120 and 31821002) to WY

Naunyn Schmiedebergs Arch Pharmacol 391:12471255 Shalkami A-GS, Hassanein EH, Sayed AM, Mohamed WR, Khalaf MM, Hemeida RA (2021) Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence