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Developing sperm are unusually vulnerable to oxidative damage: their membranes are packed with polyunsaturated fats, they carry very little internal repair machinery, and they generate a lot of reactive oxygen species while making energy to swim

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doi: 10.1159/000539005

Someone who has run a single GLP-1 compound, hit a wall around month four, and wants to push past it is close to the ideal candidate, because the amylin pathway addresses exactly the satiety gap that tends to reopen at that stage