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While other purification methods separate molecules based on size (e.g., gel filtration, size-exclusion chromatography) or ionic interaction (e.g., ion exchange chromatography), affinity purification works by manipulating certain molecular properties and binding interactions between molecules

This difference impacts dosing frequency and therapeutic consistency

M., Zheng, Y., & Tavassoli, T

(6) neurotrophic agents offer the ability to facilitate synaptogenesis, neurogenesis and neuroprotection thus greater research attention must be directed toward creating small molecule analogs designed to penetrate the BBB and activate these brain systems