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The "energy footprint" of urban areas has always extended over increasingly large basins, shaping distant and detached territories and creating "reciprocal landscapes." For example, for much of the 20th century, hydropower production has particularly impacted alpine territories near urban areas, marginal and fragile regions both in socio-economic terms and in terms of representation and self-determination

LL, WH, and PL: conceptualization, project administration, and writing-review and editing

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By understanding its relationship with other IGF-1 isoforms like MGF, its systemic effects, and its regenerative potential, researchers and practitioners can better appreciate its role in performance, recovery, and longevity optimization.