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336 The CONFIRMS trial provided evidence that a daily dosage of 80 mg of febuxostat is more efficacious in lowering serum uric acid levels than a 300 mg daily dose of allopurinol
The conserved Ser-His-Asp catalytic triad forms the active centre of ESTR, which structurally displays the distinctive / hydrolase fold structure
In one single-center trial of 72 subjects using a controlled-adverse-environment model, the T4 eye drop did not meet its co-primary endpoints (ocular discomfort and inferior corneal staining) at the primary time point, but it did produce statistically significant improvements on several secondary endpoints, including central and superior corneal staining, with no adverse events reported
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