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This is why subcutaneous injection remains the primary clinical delivery route, a point that has direct implications for the dosage chart below

The identification of novel biomarkers, such as melatonin metabolites, oxidative catabolites, DNA methylation patterns, and circulating miRNAs, represents a critical step toward developing reliable tools for early detection and individualized risk stratification 2

Without enough B12, the body may struggle to produce enough energy to sustain normal bodily functions, leading to tiredness and lethargy during the day and difficulty sleeping at night

No significant differences in hematological or serum biochemical parameters were observed between any treatment group and the control group (Additional file 2: Tables S8S9)