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Finally, the tissue sections were washed thoroughly with PBS, counterstained with DAPI and imaged under a laser scanning confocal microscope (FV-1000, Olympus, Japan)

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Mechanistically, FSP1 catalyzes the regeneration of CoQ10 (ubiquinone) through /nicotinamide adenine dinucleotide phosphate (NADPH) to CoQ10H2 (ubiquinol), and CoQ10H2 act as a lipophilic antioxidant to trap free radicals to suppress lipid peroxidation in the cell membrane, finally inhibit ferroptosis

doi: 10.1111/ene.12297 189 RubegniA.BattistiC.TessaA.CeraseA.DocciniS.MalandriniA.et al