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By doing so, antioxidants help maintain the structural integrity of the BBB and reduce the entry of harmful substances into the brain [143,210]

The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) will directly compare one representative medication from four different classes: sulfonylureas (glimepiride), dipeptidyl peptidase-4 (DPP-4) inhibitors (sitagliptin), glucagon-like peptide-1 (GLP-1) receptor agonists (liraglutide) and basal insulins (glargine) in a long-term clinical trial in patients with diabetes for 10 years or less [6]

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