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| DOI: 10.1111/jocd.12910 Copyright 2019 John Wiley & Sons, Ltd

2 Scientific basis for PBM in KOA treatment The efficacy of PBMT rests upon well-established physical and molecular foundations governing light-biological tissue interactions

Morning intake is great for consistency and satiety, while night-time intake supports the body's natural tissue repair and skin regeneration that happens during sleep

CCO is the terminal enzyme in the mitochondrial electron transport chain (ETC) ( During PBM for KOA, this molecular cascade activates CCO in synovial macrophages, releasing NO that collectively restarts mitochondrial respiration and initiates downstream signalling networks ( Figures 1 , 2 )