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Painold et al., 2019)

The multifaceted impact of IF on the gut microbiome axis highlights its potential as a sustainable, non-pharmacological intervention for managing gastrointestinal and metabolic disorders [80,81,82] (Table 3)

The clinical potential of this approach is underscored by the approval of istradefylline in Japan and the United States as an adjunct therapy for PD patients experiencing motor fluctuations, representing the most advanced A 2A receptor antagonists in clinical development [480482]

This cascade of events, involving the inhibition of complex I and subsequent AMPK activation, constitutes a fundamental mechanism underlying Metformins therapeutic effects across diverse disease contexts