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This enzymatic overactivity is strongly associated with obesity, insulin resistance, and metabolic syndrome

[DOI] [PMC free article] [PubMed] [Google Scholar] 947.Barbosa P., Pinho A., Lzaro A., Rosendo-Silva D., Paula D., Campos J., Tralho J.G., Pereira M.J., Paiva A., Laranjeira P., et al

Fundamental questions remain regarding the future prospects of this line of drug development, including questions concerning safety and tolerability, efficacy, doseresponse relationships and therapeutic mechanisms