In the past, traditional treatments created a dependency on the therapy
Citrate buffers, on the other hand, tend to cause more pain at higher concentrations, so they are typically limited to lower concentrations, often under 10 mM, for injectable formulations
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FIGURE 1 2 Heme Synthesis Heme synthesis is a ubiquitous process catalyzed by 8 enzymatic steps that take place in the cytosol and the mitochondria (summarized in Figure 2)