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PMC 12128567

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The aerosol smoke samples were collected in a bag with dilution air to allow common particle characterization techniques to be utilized, while the chemical composition and total particulate matter (TPM) measurements were completed on smoke collected on quartz filters immediately downstream of the cigarette or joint

Nicotine could harm endothelial cells or decrease the function of cNOS at the ulcer site (mostly granulation tissues) and the surrounding area, which would impede NO generation