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However, if a catalyst evolves for a more specific function, it may be advantageous to suppress the activity with alternative substrates

Dermatol Pract Concept 12(4):e2022179

The low-selenium condition in combination with three mycotoxins, deoxynivalenol (DON), nivalenol (NIV), and T-2, yielded pro-catabolic changes and hypertrophic phenotype of chondrocytes, as evidenced by the loss of aggrecan and type II collagen (COLII) and the increase in COLX and matrix metalloproteinases (MMPs) expression, respectively 71

The latter is referred to as the senesence associated secretory phenotype (SASP) and this is considered to be driving many aspects of functional decline