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The enzyme CHAC1 (CHAC1/BOTCH for blocking NOTCH) is a key regulator of this process (Figure 6)

Gastroenterology 114 , 842845 (1998)

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This heterogeneity likely stems from the existence of multiple ER splice variants (ER15) with differing functions, as well as the varying specificity of antibodies used in immunohistochemistry (IHC) studies [16]