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Supplemental CAT is shown to alleviate OxS in the GI tract and improve gut microbiota 576

Common Xenobiotic Induction Pathways and Effect On Liver Morphology Induction Involving Constitutive Androstane Receptor Barbiturates and chemicals that induce CYP2B initially interact with the constitutive androstane receptor (CAR) that translocates to the nucleus and dimerizes with the retinoid-X-receptor (RXR)

It's a very real physiological pathway where intestinal dysfunction can directly impact brain health

Improved clinical outcomes with concurrent decrease in ammonia concentration were seen in 60% of patients following treatment adjustment