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Liver biopsies obtained from both NASH patients and rodent NAFLD models demonstrated defective mitochondrial respiratory chain function together with altered mitochondrial structure, presented as enlarged mitochondria, rounded cristae and loss of the typical dense mitochondrial granules, as well as an epigenetic modification on mitochondrial DNA [65, 66]

There are three pathways of glutathionylation

High-dose (0.1 M) docetaxel- and paclitaxel-treated cells resulted in a G2/M arrest, followed by generation of polyploidy or apoptosis

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