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How it works: Chromium picolinate is a highly absorbable form of chromium that helps reduce appetite and cravings by impacting neurotransmitters involved in regulating mood and eating behavior ( Effectiveness: A review of 11 studies in 866 overweight or obese people found that supplementing daily with 1371,000 mcg of chromium for 826 weeks led to reductions in body weight by 1.1 pounds (0.5 kg) and body fat by 0.46% ( Side effects: Potential side effects related to chromium picolinate include loose stools, vertigo, dizziness, headaches and hives ( Summary Some research has shown that chromium picolinate may be effective in reducing appetite and encouraging weight loss