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In addition to plants, H2O2 has been also demonstrated to act as a secondary messenger in mammalian cells, mediated through the activation of transcription activators, such as nuclear factor kB (NF-kB) (Schreck et al., 1991) and AP-1 (activator protein-1

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Studies in vitro have shown that it can reduce levels of pro-inflammatory cytokines such as TNF- and the p-NFB marker, highlighting an overall anti-inflammatory effect