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Disruptions in these metabolic pathways, whether due to genetic mutations, hepatic dysfunction, or altered bile composition, lead to bilirubin supersaturation in bile, a key factor in gallstone pathogenesis

Recently, Chen et al (187) developed a folic acid-decorated, manganese dioxide-coated mesoporous silica nanoparticle to co-deliver fluvastatin sodium (MCT4 inhibitor) and metformin, effectively targeting tumor lactate metabolism by promoting lactate production and inhibiting lactate efflux, thereby exacerbating intracellular acidosis and inducing cancer cell death

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10.1016/j.jep.2009.04.005 87