Its pathogenesis primarily involves immune dysregulation, including breakdown of immune tolerance, alterations in the immune microenvironment, and dysregulation of T cell subsets (158, 159)
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Integrated Structural, Vascular & ImmuneLinked Signaling Frameworks Ingber D.E
Furthermore, NRF2 inhibits the nuclear factor kappa-B (NF-B) signaling pathway, thereby decreasing inflammation, joint pain, and the breakdown of cartilage extracellular matrix, while also mitigating cell aging and death