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GLP-1 receptor agonists cause fatigue primarily through indirect mechanisms including substantial caloric restriction from appetite suppression, gastrointestinal side effects leading to dehydration and nutritional deficits, and metabolic adaptation during weight loss

The glucose-dependent nature of semaglutides insulin secretion generally results in a lower intrinsic risk of hypoglycemia compared to insulin or sulfonylureas, but the combination effect must be carefully managed

Therefore, it is recommended that latent or active amebiasis be ruled out before initiating corticosteroid therapy