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Bariatric surgery alters gastrointestinal anatomy and physiology, which can affect medication tolerability and efficacy, though tirzepatide's subcutaneous administration bypasses concerns about altered GI absorption

Mitochondrial respiration and fatty-acid oxidation Cell and mouse studies reported increased mitochondrial respiration, oxygen consumption, oxidative muscle features, fatty-acid oxidation, and resting energy expenditure

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Vincristine caused a sharp increase in histone 3 phosphorylation at serine 10 (pS10-H3), likely due to its interference with mitotic spindle assembly, causing mitotic arrest ( Supplementary Figure S7A )