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DOI: 10.1016/j.bbadis.2011.12.010 56

Our data indicate an increased risk of vomiting and nausea side effects associated with the Gln allele in tirzepatide-treated patients, which may result from a diminished ability of the GIP component of the drug to buffer the nausea-inducing effects of the GLP1 component

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Moderate HO-1 induction provides neuroprotection, excessive upregulation may paradoxically accelerate ferroptosis through iron overload, highlighting the need for precise therapeutic modulation