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doi:10.1371/journal.pone.0162590.g008 Diclofenac, L-NAME, L-Arginine and BPC 157 in Short-Bowel Rats PLOS ONE | DOI:10.1371/journal.pone.0162590 September 14, 2016 12 / 18 Of note, in diclofenac-treated rats, in all groups and combinations, BPC 157 consistently exhibited a beneficial effect and in particular, might have nullified the effect of L-NAME with lesions markedly below diclofenac-control values

There are no long-term studies evaluating the safety of these supplements in dogs. He points to one published paper on BPC-157 that included six dogs

Gut Function and Intestinal Lining Support Because BPC 157 peptide originates in the stomach, its effects on gut function are especially potent and well-studied