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91 In the methionine cycle, methionine is sequentially converted into s -adenosyl-l-methionine (the methyl donor for all methylation reactions in the cell) and s -adenosyl-l-homocysteine

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FIGURE 3 Discussion Unfortunately, the incidence of suicide is increasing and now represents the leading cause of mortality for people aged 15 to 44 years ( While the risk of death and suicide attempts is lower during and shortly after pregnancy than in the general female population, suicides account for up to 20% of all postpartum deaths and represent a leading cause of mortality in the peripartum period, which corroborates the high prevalence of suicide risk in our sample of women ( Under basal physiological conditions, there is a controlled balance between pro-oxidant molecules and antioxidant molecules, and an imbalance between these molecules is called oxidative stress ( Other studies examining blood serum and plasma GSH concentrations have also identified significantly lower GSH in MDD patients compared with healthy patients ( in vivo levels of GSH in the COC of unmedicated adults with MDD versus healthy controls ( Oxidative damage and redox dysregulation appear to play important roles in the pathogenesis of psychiatric disorders due to the brains vulnerability to the toxic effects of oxygen-free radicals ( Mechanisms of oxidative stress have been implicated in the pathogenesis of psychiatric disorders (47)