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It is also important to consider the fact that many smokers use flavors to transition away from cigarettes and by extension, tobacco altogether. If such health implications are not considered, the ban may inadvertently do more harm than good, Fowler-Jones said

[79] demonstrated that Plasma sE-cadherin levels were significantly lower in patients with COPD and symptomatic smokers than in healthy smokers and healthy non-smokers, and sE-cadherin levels were associated with the severity of airflow limitation in COPD and symptomatic smokers plasma

A less mathematical explanation of PCA can, for example, be found in Cheng 20

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