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Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis

Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

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10.5 Transformative potential of nanotechnology-enabled redox sensing in cancer Redox-sensitive nanotechnology holds transformative potential for cancer therapy by targeting the distinct oxidative imbalances present in tumor microenvironments