used ultra-high-performance liquid chromatography to determine the content of paeoniflorin in Paeonia lactiflora Pall (Ren et al., 2015)
however, it is a rare side effect
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
If irritation continues, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use and contact your provider