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Individuals with aldehyde dehydrogenase 2 (ALDH2) deficiency, most prevalent in East Asian populations, accumulate acetaldehyde during alcohol metabolism, producing severe flushing, tachycardia, and nausea even at low intake levels

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PMID 11695986

In the inhibitory pathway, the protease cleaves a region of the serpin, generating an irreversible covalent protease-serpin complex