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these are sold in flavours including citrus, peppermint, wintergreen and fruit.7 Alongside BAT and Swisher International, two other manufacturers are also currently present in the USA: Lucy sells both recreational nicotine gum (available in wintergreen, pomegranate, cinnamon, mango, mint, berry citrus and espresso flavours)13 and nicotine lozenges (available in mint, cherry ice and citrus).14 Under the brand name Solace, Lucy also produces a recreational nicotine gum with a soft, chewable texture and a crispy outer coating (available in cinnamon, cool mint and fruit medley flavours).15 Alongside these products, nicotine pouches are also available under the Rogue, Velo and Lucy brands

Extracted from tobacco, nicotine is the main cause of addiction that harms the body

METHOD Traditional asystematic review of papers indexed on the LILACS and MEDLINE databases from 1960 to 2009

Clara cell protein in serum and bronchoalveolar lavage, Eur Respir J