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Skinner et al., 2019

They neutralise harmful free radicals, which may be generated by environmental factors such as UV radiation, pollution and poor diet

3.4 Other regulatory mechanisms of ferroptosis There are several classical signaling pathways, which either synergize with ferroptosis or act as upstream regulatory signals that influence cancer cell survival and proliferation, including PI3K/Akt, Wnt/-catenin, p53, ACSL4, Caspase-1-dependent pyroptosis, and AMP-activated protein kinase (AMPK)/ Beclin1 (BECN1) signal pathways