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It also can form metal complexes that reduce the toxicity of the metals and facilitate their further excretion from the body [110,111,112]

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It's a systemic metabolic modulator, not just a fat loss agent

In addition, in PC12 and N2a cells, low-concentration administration of berberine significantly reduced the amount of ROS generation, lipid peroxidation, and DNA fragmentation, and at the same time increased glutathione content and superoxide dismutase activity (Sadeghnia et al., 2017)