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Additionally, multiple studies have substantiated the beneficial effects of E2 on metabolic and visceral obesity and its protective role in OSAHS (43, 44)

In those experiments, pretreatment with the peptide enhanced subsequent responses to growth hormone stimulation, including increased cell viability, elevated proliferating cell nuclear antigen (PCNA) expression, and greater JAK2 phosphorylation activity [5]

Patients with autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and T1D, have been shown to have lower levels of CTLA4 mRNA (85)

* Indicated significance among the 4 studied groups